Holy Cross Roman Catholic Church is a historic Roman Catholic church complex located within the Archdiocese of Baltimore in the Federal Hill neighborhood of Baltimore, Maryland, United States.

The church has a cruciform plan and features a 200-foot steeple composed of a 125-foot tower and a 75-foot copper-clad spire.

[2] Holy Cross Roman Catholic Church was listed on the National Register of Historic Places in 2002.

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