While the school is primarily English-medium, there is also a smaller Marathi-medium section that runs in parallel from the fifth to the tenth standard.

Holy Family High School was founded in 1944 as a parish institution in an old, single-storied structure by Fr.

It was improved and extended with the help of student efforts such as donations, raffles, and school fêtes.

It had an inadequate playground and poor sports facilities, requiring the use of the Vinayalaya Jesuit seminary grounds, behind the school and church buildings.

The building was extended in the 1970s to have multiple stories, with additional classrooms and a school hall.

A mini-stadium was built on the old school ground using funds donated by Jitendra Shah.

D'Souza as vicar and Francis Gonsalves as principal, the new school building was formally inaugurated by Simon Cardinal Pimenta, the archbishop of Bombay.