[1] Holy Redeemer High School was founded in 1882 by the Sisters, Servants of the Immaculate Heart of Mary (IHM) with the assistance of the Redemptorist Fathers (CSsR).

The Basilian Fathers administered Holy Redeemer High School for approximately five years until the time of its closing.

The Marist fathers left Holy Redeemer at some point in the late 1940s/early 1950s and the I.H.M sisters took over administration of the combined girls and boys high school at that time.

Later, St. Andrew's (in 1983), St. Hedwig's (in 1990) and St. Alphonsus' (in 2003) closed, leaving Holy Redeemer the only Catholic high school on the southwest side of Detroit.

Detroit Cristo Rey is under the sponsorship of the Basilian Fathers and the Sisters, Servants of the Immaculate Heart of Mary.

In addition to their athletic teams, the high school used to hold professional basketball games for a season for the Detroit Gems, who eventually became the Los Angeles Lakers.

[5] The parish was the centerpiece of the 1987 movie The Rosary Murders, starring Charles Durning and Donald Sutherland, filmed on location at Holy Redeemer and the surrounding neighborhood.