Holy See–Malaysia relations (Latin: rationes Sancta Sedes et Malaesia; Italian: Relazioni tra Santa Sede e Malesia; French: Relations entre le Saint-Siège et la Malaisie; Malay: Hubungan Malaysia–Takhta Suci; Jawi: هوبوڠن مليسيا–تختا سوچي) are foreign relations between the Holy See and Malaysia.

In 2002, Prime Minister Mahathir Mohamad visited the Vatican to meet Pope John Paul II.

[3] During the second visit of the next Malaysian Prime Minister, Najib Razak and Pope Benedict XVI at the Apostolic Palace in Castel Gandolfo, an agreement to establish diplomatic relations between the Holy See and Malaysia was finalised.

[7] The Holy See previously had an apostolic delegation, based in Bangkok, for the country.

[10] In 2016, Malaysia appointed Bernard Giluk Dompok as the first resident ambassador to the Holy See.