The Holy See (Vatican City) and Mexico have a long-standing contact and foreign relations.

The majority of Mexicans practice the Catholic faith, however, since the adoption of the current Constitution in 1917, Mexico is a secular nation.

[1] The Holy See and Mexico broke diplomatic relations after Mexican President Benito Juárez confiscated church property between 1856 and 1861.

[3] In 1926, after several years of the Mexican Revolution and insecurity, President Plutarco Elías Calles, leader of the ruling Institutional Revolutionary Party, enacted the Calles Law, which eradicated all the personal property of the churches, closed churches that were not registered with the State, and prohibited clerics from holding public office.

[4] The law was unpopular, and several protesters from rural areas fought against federal troops in what became known as the Cristero War.