Holy Spirit Lyceum (French: Lycée du Saint-Esprit) is a public Catholic secondary school located in Gihosha, Bujumbura, Burundi.

The school was founded by the Rwanda Burundi Region of the Society of Jesus in 1952; and it covers ages 11 through 18 and has about 920 students.

It remains in Kamenge but, following the redivision of the city into new administrative units, it was designated as being in the zone of Gihosha.

Teaching is in French while languages taught include the native Kirundi as well as Swahili and English.

[citation needed] Past rectors include Guillaume Ndayishimiye (1990-2000 and 2011-2016), Ignace Samurenzi (2000-2001 and 2003-2011), Robert Albertijn (2001-2003 ) and Bernard Karerwa(2016- ).