The preschool program is located at 4465 Northside Drive on the lower level of Holy Spirit Catholic Church, adjacent to the 57,000 sq ft (5,300 m2) Upper School campus, which opened in the fall of 2005.

[citation needed] The elementary campus is in Sandy Springs while the preschool and upper school are in Atlanta.

The school's Classics department describes its program as being "designed around an awareness of the historical significance of the Greek and Latin languages as foundations for the Western intellectual tradition and the history of the Catholic Church.

[7] The school offers a number of student athletics programs, including cross country running, soccer, baseball, basketball, cheer leading, clay targets, golf, swimming, tennis, track and field, and volleyball.

[9] At the close of their 2013-14 season, Holy Spirit Prep announced they would return to the Georgia Independent School Association's football league.

The house point system works by enforcing positive behavior, such as volunteering for service opportunities, holding a door, helping teachers carry things, or cleaning the boards.

Holy Spirit College,[16] an outgrowth of the preparatory school, is a Georgia Non-Public Secondary Education Commission authorized degree-granting institution.