The house then passed to Charles Carroll III, (the grandson), who lived there until he inherited the rural landmark family estate, Doughoregan Manor (in modern Howard County), from his grandfather.

In 1839, Charles Carroll III sold Homewood to Samuel Wyman [Wikidata], a Baltimore merchant, who lived there with his family until 1865.

Johns Hopkins University now operates Homewood Museum, which opened to the public in 1987, and its Federal-style architecture, with its red brick and white marble, serves as the inspiration for the campus' design.

Homewood exhibits a Palladian-inspired five-part plan, that reflects harmony in the proportions and sophisticated details in its construction.

The five-part plan is based on a central block comprising the main residence, with flanking pavilions or dependencies linked to the center by hyphens.

The house, while planned and massed in the Georgian style, uses Federal-style detailing, reflecting influences of the English architecture of Robert Adam.