John Spencer (13 May 1708 – 19 June 1746) was an English politician who sat in the House of Commons from 1732 to 1746.

Spencer was born on 13 May 1708 and was the youngest son of the 3rd Earl of Sunderland, the First Lord of the Treasury and Lord President of the Council under George I, and his second wife, Lady Anne Churchill, who served as Lady of the Bedchamber to Queen Anne from 1702 to 1712.

He was educated at Eton College in about 1722, and he undertook a Grand Tour through France, Switzerland and Italy between 1725 and 1727.

[2] In 1732, Spencer succeeded his cousin, William Godolphin, Marquess of Blandford, as Member of Parliament (MP) for Woodstock, a seat he held until 1746.

He was involved in the foundation of the Foundling Hospital, famously championed by Thomas Coram, William Hogarth and others.