The bike is officially sold in Indonesia, Japan, Hong Kong, Macau, Thailand, and Malaysia.

[13][better source needed] The basis for the CBR250RR was Honda's Light Weight Super Sports Concept that was shown at the 2015 Tokyo Motor Show.

Honda said that, "attention to detail in functional components give the Light Weight Super Sports Concept a quality beyond its class, indicating the design direction of Honda's next generation lightweight super sports models.

The compression ratio is increased by changing the piston shape, using smaller diameter balancer shaft to further increase maximum engine rotation speed in order to minimize friction loss, optimization of valve spring load, thorough reduction of friction by adding a notch at the lower end of cylinder to reduce pumping loss in the engine, addition of tin plating to the piston ring groove, adoption of high strength carburized connecting rod, optimization of the ignition timing, intake system parts, and changes to the internal structure of the muffler.

The friction of the front inverted fork is reduced and the damping force is optimized to improve handling.