Production began on November 14, 2001 and was the first Honda factory to both produce engines and assemble vehicles under the same roof.

[1] In 2004 the Honda Pilot was added as the second vehicle the factory was producing.

[2] In 2009 the Alabama factory picked up production of the Honda Ridgeline.

[5][6][7] From May 2017 Honda started to dual-source Acura MDX from both Alabama and East Liberty Auto Plant[8][9] until Alabama switched from producing MDX to additional Pilot at the end of 2017.

[10] In 2019, Honda Alabama produced over 351,000 vehicles and V6 engines.