Honda Yasushige (本多康穣, January 23, 1836 – February 28, 1912) was the 14th (and final) daimyō of Zeze Domain in Bakumatsu period Japan[1] Before the Meiji Restoration, his courtesy title was Shuzen-no-kami, and his final Court rank was Senior Second Rank.

During the Bakumatsu period, he served as a guard for the Kyoto Imperial Palace, and served as a guard in the retinue for Princess Kazu-no-miya on her journey to Edo to marry Shogun Tokugawa Iemochi.

He later served as a guard during Emperor Kōmei's visit to Iwashimizu Hachiman-gu to pray for the deliverance of Japan from the Western Powers and their kurofune.

The clan was rent internally between supporters of the shogunate, and the radical pro-Sonnō jōi faction seeking to overturn the shogunate, and as a result, Shogun Tokugawa Iemochi was forced to cancel his plans to stop overnight at Zeze Castle en route to Kyoto to meet with Emperor Kōmei.

Following the Meiji restoration, Honda Yasushige was one of the first daimyō to agree to surrendering his title to the new government, and in June 1869 received appointment as imperial governor of Zeze.