Among the Mexicans who joined the Army Allied Protector of the Law, commanded by the Honduran Francisco Morazán during the so-called Central American Civil Wars, were General Agustín Guzmán, a native of Quetzaltenango and many others.

In June 2009, Honduran President Manuel Zelaya was ousted in a coup d'état and taken to neighboring Costa Rica.

Many Honduran migrants flee to the United States for better economic opportunities and/or to escape rampant crime and gang violence in their country, especially from the MS-13/Mara Salvatrucha.

[6] In 2018, several hundreds to a few thousands Hondurans formed part of the Central American migrant caravans and traversed all of Mexico to the northern city of Tijuana to request asylum in the United States.

[9] In January 2022, Mexican Foreign Minister Marcelo Ebrard paid a visit to Honduras to attend the inauguration of President Xiomara Castro.

[30] Hondura's main exports to Mexico include: electrical wires and cables, palm oil, sugar cane, clothing, and motor vehicles parts and accessories.

[30] Several Mexican multinational companies such as América Móvil, Cemex, Grupo Bimbo and Gruma (among others) operate in Honduras.