There is close cooperation between the two countries, particularly in the areas of the war on drugs[1] while the National Port Authority in Puerto Cortés is part of the U.S. Bureau of Customs and Border Protection's Container Security Initiative.

Such as merchandise smuggling, geostrategic interests of the English crown in the Mosquitocoast and the Bay Islands, and the influence of the independence of America among the Criollos and the enlightened Hispanic elite.

Honduras, given its strategic geographic location and its wealth in natural resources, began to attract American interest although its influence on the country was not as strong as it was several decades later.

During this period, the diplomat E.G Squier arrived, who brought descriptions about the country to the University of New York and who saw several archaeological sites and interviewed indigenous peoples in the area.During the end of this century when we began to see the growth of US capital investment on Honduran soil, opening companies such as the Rosario Minning Company, this due to the so-called Liberal Reform made by President Marco Aurelio Soto that allowed foreign investment.

Although at the beginning, at the initiative of President Tiburcio Carias Andino, he maintained a certain diplomatic closeness with the Axis, however he slowly distanced himself from them until after the Pearl Harbor attacks, he declared war on the Empire of Japan, Germany, and Italy.

Starting in the 60s, Ramon Villeda Morales became president, who maintained close ties with the administration of John F. Kenendy, with the United States being the investor in humanitarian projects in the country.

[16] The United States maintains a presence at the Soto Cano Air Base in Comayagua; the two countries conduct joint peacekeeping, counter-narcotics, humanitarian, disaster relief, and civic action exercises.

U.S. troops conduct and provide logistics support for a variety of bilateral and multilateral exercises, medical, engineering, peacekeeping, counternarcotics, and disaster relief.

This partnership involves a joint military unit at Soto Cano Air Base, focusing on building relationships not only with Honduras but also with other Central American countries.

[17] In early 2023, the U.S. and Honduras engaged in Strategic and Human Rights Dialogues, reaffirming their commitment to jointly tackle the root causes of irregular migration and forced displacement.

[18] In early 2025, Honduras threatened to expel U.S. troops if President-elect Donald Trump pursued a mass deportation of refugees and asylum seekers entering the United States from Central America.

[19] In 2004, the United States signed the U.S.-Central America Free Trade Agreement (CAFTA) with Honduras, El Salvador, Nicaragua, Guatemala, Costa Rica, and the Dominican Republic.

Additionally, CAFTA is expected to solidify democracy, encourage greater regional integration, and provide safeguards for environmental protection and labor rights.

U.S.-Honduran trade is dominated by the Honduran maquila (factory) industry, which imports yarn and textiles from the United States and exports finished articles of clothing.

Honduras presents several attractive features for international and domestic investors, such as its proximity to U.S. markets and the benefits provided by the Dominican Republic-Central American Free Trade Agreement (CAFTA-DR).

The U.S. Joint Task Force Bravo (JTF-B), stationed at the Honduran Soto Cano Air Base, plays a vital role in supporting combined exercises in Honduras and in neighboring Central American countries.