Yūta Takemoto, Takumi Mayama and Shinobu Morita are three young men who live in the same apartment complex and are students at an art college in Tokyo.

The group comes to include Ayumi Yamada, a master of pottery who is well known by her nickname "Tetsujin" (Iron Lady), who becomes very close to Hagu.

While Ayumi is popular with many young men, she falls in love with Takumi, who does not reciprocate her feelings and considers her a very dear friend.

Instead, Takumi pursues an older woman, Rika Harada, a widowed friend of Professor Hanamoto who runs an architecture studio she founded with her late husband.

Written and illustrated by Chika Umino, Honey and Clover debuted in Takarajimasha's shōjo manga magazine[4] Cutie Comic [ja] on April 24, 2000.

[19] All the series' chapters were made available for free on Hakusensha's Young Animal website from August 21 to September 11, 2023.

[20] The manga is licensed in North America by Viz Media, which began serializing it in Shojo Beat magazine in August 2007.

[40] The second season, Honey and Clover II, consists of 12 episodes, aired from June 30 to September 15, 2006.

[46] Viz Media subsequently released the entire series across three DVD box sets from September 22, 2009, to March 16, 2010.

[47][48][49] In May 2019, Discotek Media announced the license of the series;[50] both seasons were released on two Blu-ray Disc sets on March 3 and April 28, 2020, respectively.

It was directed by Masahiro Takada from a screenplay by Masahiko Kawahara and Masahiro Takada, and starred Arashi's Sakurai Sho as Takemoto, Yū Aoi as Hagu, Yūsuke Iseya as Morita, Ryō Kase as Mayama, and Megumi Seki as Ayumi.

Written by Kaneko Shigeki, and directed by Masaki Tanamura and Hiroaki Matsuyama, the show starred Toma Ikuta as Takemoto, Riko Narumi as Hagumi, Hiroki Narimiya as Morita, Osamu Mukai as Mayama, and Natsuki Harada as Ayumi.

[61] The manga was adapted into a Taiwanese drama titled (Chinese: 蜂蜜幸運草; pinyin: Feng Mi Xing Yun Cao) starring Lego Lee as An Zhu Ben (Takemoto), Chiaki Ito as Hua Ben Yu (Hagumi), Eddie Peng as Ren Sen Tian (Morita), Joe Cheng as Den Zhen Shan (Mayama), and Janine Chang as He Ya Gong (Ayumi).