In 1958, the businessman Victor Zirinsky was appointed Israel's Honorary Consul in Hong Kong and served in this capacity until Israel's diplomatic presence was formally established in 1985, when Reuven Merhav was appointed to be the Consul General as a joint representative for Hong Kong and Macau.

[1][2] Hong Kong's interest in Israeli high-tech start-ups has led to increasing economic ties between the two entities.

InvestHK, a department of the Hong Kong Government, has stated it will help Israeli expatriate entrepreneurs set up operations in the city.

Promising Israeli start-ups are enrolled in a business incubator and accelerator program called StartMeUpHK that offers investments of $500,000, a trip to Hong Kong, mentorship programs with East Asian business executives, and admission to major high-tech entrepreneurship and investment events hosted in the region.

[8] However, the airline's flights between the two cities were cancelled in December 2023, following deteriorating situations in Israel due to the Israel-Hamas War.