Since the beginning of the 20th century, Swiss businessmen, as well as Catholic and Protestant missionaries – most of them from the Basel Mission – settled in Hong Kong.

Hong Kong is Switzerland's third largest export destination (7.8%), only after Germany (16%) and United States (10%).

[6][dead link‍] In 2022, Hong Kong's exports to Switzerland were predominantly in the precious metals sector, with ores, concentrates, and related materials (excluding gold) making up 52.4% of its total exports.

[6] From Hong Kong, Secretary for Commerce and Economic Development, Gregory So, visited Switzerland twice in December 2016 and January 2017.

In December 2016, the Secretary for Security, Lai Tung-kwok, visited Switzerland and met with officials at the federal level responsible for refugee matters.