Honghe Hani and Yi Autonomous Prefecture (simplified Chinese: 红河哈尼族彝族自治州; traditional Chinese: 紅河哈尼族彝族自治州; pinyin: Hónghé Hānízú Yízú Zìzhìzhōu; Hani: Haoqhoq Haqniqssaq Haqhholssaq Ziiqziifzel; Yi: ꉼꉸꉳꆃꁈꆃꁈꊨꏦꍓ) is an autonomous prefecture in Southeast-Central Yunnan Province, China, bordering Vietnam's Lào Cai and Lai Châu provinces to the south.

Its name is derived from the Hong (Red) River and the two major ethnic minority groups who live there: the Yi and the Hani.

Honghe has an area of 32,929 square kilometres (12,714 sq mi) and its seat is Mengzi.

It was added to the list on 22 June 2013, bringing the total number of World Heritage Sites in China to 45.

The prefecture is subdivided into 13 county-level divisions: 4 county-level cities, 6 counties, and 3 autonomous counties: At the end of 2019, Honghe Prefecture had 4.775 million residents, of which 61.3% belonged to ethnic minorities.