Hopelchén (Yucatec Maya: "place of five wells") is one of the 13 municipalities in the Mexican state of Campeche.

The municipal seat, and largest settlement, is the city of Hopelchén.

[1] Other than the city of Hopelchén, the municipality had 269 localities, the largest of which (with 2010 populations in parentheses) were: Bolonchén de Rejón (3,975), Vicente Guerrero (3,198), classified as urban, and Dzibalchén (2,340), Ukum (2,019), Xmabén (1,228), Suc-Tuc (1,179), and Chunchintok (1,086), classified as rural.

It covers 7,460.27 km2, accounting for 13% of the state's total surface area.

The Maya archaeological sites of Chunan-Tunich, Dzibilnocac, Santa Rosa Xtampak, Hochob and Pak-Chén are located in the municipality.