[2] Mark Hoppus stated "I am stoked to join the Fuse family and have a show where I can talk about a topic that I'm passionate about, music.

More importantly, I'm excited to force millions of people to watch me on a weekly basis on national television."

According to Fuse senior vice president of programming and development Sal LoCurto, "A Different Spin with Mark Hoppus was developed to complement the wide variety of music programming on Fuse - including live concerts, festival coverage and in-depth interview series with the biggest names in music."

On August 5, 2010, Hoppus revealed the co-host of the show would be comedian Amy Schumer.

On December 11, 2011, Hoppus welcomed bandmate Tom DeLonge's band Angels & Airwaves, on which Mark joked he "cheats" on him with.