Horatio Clifford Claypool (February 9, 1859 – January 19, 1921) was a three term U.S. Representative from Ohio.

He was the father of Harold Kile Claypool and cousin of John Barney Peterson.

He studied law and was admitted to the bar in 1882 and commenced practice in Chillicothe, Ohio.

He was interred in Grandview Cemetery, Chillicothe, Ross County, Ohio, USA.

This article incorporates public domain material from the Biographical Directory of the United States Congress