During the 17th century, Horní Jiřetín was affected by the Thirty Years' War and by the great plague epidemic in 1680.

From the 17th century, Horní Jiřetín, divided by the stream Jiřetínský potok, was mainly governed by the Lobkowicz and Waldstein families.

In the past, the inhabitants of Jiřetín subsisted mainly on fishing in Lake Komořany, ore mining and various forms of agriculture, mainly arboriculture.

[3] Today, a significant part of the municipal territory is occupied by a lignite surface mine, Lom ČSA.

It was built in the early Baroque style in 1694–1700 according to design of the architect Jean Baptiste Mathey.