There he worked with William Hugh Feldman on animal models of tuberculosis infection and was an associate professor of medicine until 1949.
[5] When streptomycin was isolated from Streptomyces griseus by Albert Schatz, Elizabeth Bugie, and Selman Waksman at Rutgers University,[6] Hinshaw and William Hugh Feldman, working together at the Mayo Clinic, requested a sample of streptomycin for testing in their guinea pig animal model of tuberculosis infection.
After streptomycin proved effective for treating infected guinea pigs, Karl Hamilton Pfuetze, M.D.
(1908–1990), superintendent and medical director at the Mineral Springs Sanatorium in Cannon Falls, Minnesota, contacted Dr. Hinshaw, in October 1945, concerning Pfuetze's tuberculosis patient Patricia "Patsy" Jane Thomas (1922–1966).
[7] Patricia Thomas married Robert Ward Stockdale on October 8, 1947, in Mower County, Minnesota.
In 1959 he moved to San Francisco and, at 450 Sutter Street, had an active internal medicine practice specializing in pulmonology in collaboration with his elder son, H. Corwin Hinshaw, Jr., M.D.
In 1947 he was nominated for a Nobel Prize by Melvin Starkey Henderson, Henry William Meyerding (1884–1969), and Robert Delevan Mussey (1916–2015).