Geographically located to the central south of Ethiopia, with a latitude and longitude of 7°33′N 37°51′E / 7.550°N 37.850°E / 7.550; 37.850 with an elevation of 2177 meters above sea level.

[6] In 1929, a pair of missionaries settled in the town, their efforts leading to Hosaena becoming a center of Protestant Christianity in southern Ethiopia; as early as December 1949, the town hosted a Bible conference, attended by 800 persons.

"[6] Based on the 2007 Census conducted by the CSA, this woreda has a total population of 69,995, of whom 35,523 are men and 34,472 women.

The majority of the inhabitants were Protestants, with 65.74% of the population reporting that belief, 24.6% practiced Ethiopian Orthodox Christianity, 6.57% were Muslim, and 1.99% were Catholic.

Hadiya Hossana Football Club use the 5,000-capacity Abiy Hersamo Stadium for home games.