Now turned into a museum, the main hall hosts the magnum opus frescoes of muralist painter José Clemente Orozco.

The complex was founded in 1810 by the Bishop of Guadalajara in order to combine the functions of a workhouse, hospital, orphanage, and almshouse.

It owes its name to Juan Ruiz de Cabañas who was appointed to the see of Guadalajara in 1796 and engaged Manuel Tolsá, a renowned architect from Mexico City, to design the structure.

The highlight of the interior decoration is a series of monumental frescoes by José Clemente Orozco, including one of his most famed creations, the allegory of The Man of Fire (1936–39).

[2] Funded through a collaboration by the Cabañas Institute, Jalisco's cultural ministry and the Hilario Galguera Gallery in 2014, French conceptual artist Daniel Buren created a series of site-specific works in 18 of the 23 courtyards, with cloister columns wrapped in geometric patterns, vaults painted in bright hues and mirrored structures built to create distorted views of familiar surroundings.