Nevertheless, in 1880 during the conflict for the Federalization of Buenos Aires, it was used as barracks for marksmen and hospital for the wounded in the battles of Puente Alsina, Corrales and Barracas.

The Province of Buenos Aires, defeated by the National Army, gave control of the hospital to the Faculty of Medicine of the University of Buenos Aires and, on August 31, 1880, the National Government ratified that decision.

Built accordingly to the models of its time, the design was inspired by the Friedrichshain Hospital in Berlin and the lazaretto in Karlsruhe.

The construction suffered numerous delays and only in 1962 did the first services –Radiology and Otorhinolaryngology out-patient clinic- start functioning in the new hospital.

It was during the first years of the 1970s decade that the new building gained full functionality and in 1975 the demolition of the old hospital was started.