The hospital was founded by Canon Justino de Neve [es] in 1675, to be the residence of the venerable priests.

The building facade is white lime contrasting with red brick pilasters, architraves and cornices.

The nave is decorated with mural frescos by Valdes Leal: frescos in the chancel represent the invention of the Holy Cross; on the right side of the presbytery is represented San Fernando delivering the mosque to the Archbishop; on the left side is shown San Fernando before the Virgin of Antigua.

The paintings that cover the vault and the walls were made by Lucas de Valdés, son of Leal.

In the altarpiece of the Conception, the figure of San Esteban is an anonymous work of the seventeenth century, but it is attributed to Montanes.

The pulpit, made with polychrome marble and rich woods is the work of Francisco de Barahona.

The building was inaugurated by Queen Sofia on November 5, 1991, with an exhibition dedicated to Sevillian painting of the Golden Age.

There are about a dozen works of art including the Imposición de la casulla a San Ildefonso [es] by Velázquez and the Portrait of Martínez Montañés (1616) by Francisco Varela, both owned by the City of Seville.

The Focus-Abengoa Foundation has provided another canvas attributed to Velázquez, an Immaculate Conception from the early seventeenth century.