Mohammad-Hossein Saffar-Harandi (born 29 September 1953) is an Iranian politician who was minister of culture and Islamic guidance of Iran from 21 August 2005 until 23 July 2009 when he resigned after opposing the appointment of Esfandiar Rahim Mashaei as vice president.

He is the nephew of Reza Saffar Harandi, who assassinated Hassan Ali Mansoor, then Iran's prime minister, in 1965.

Harandi was deputy commander of the Islamic Revolutionary Guard Corps (IRGC) in Hormozgan (1981),[5] Kerman and other provinces.

[5] In the beginning of 1989, on the occasion of the death and funeral of Hirohito, the 124th Emperor of Japan who had ruled for over 60 years until he died on 7 January, Harandi and Mostafa Mir-Salim, Vice President, went to the Imperial Palace in Tokyo to attend the Rites of Imperial Funeral on 24 February with Mohammad Hossein Adeli, Ambassador Extraordinary Plenipotentiary in Japan, and his wife.

When he assumed his post, he stated that one of the first issues that he would combat would be the types of music that are against the values of the Republic of Iran, including rock and rap.