The comic tells the story of Hamish as he is brought from his remote island home to play for Princes Park in the Scottish Premier Division, under manager Ian McWhacker, and becomes famous for being able to hit the ball so hard that his shot could (and often did) burst the goal net.
Mouse's character was a successful and highly skillful First Division footballer despite the fact that he was very short, extremely overweight, and wore thick spectacles even while playing.
In the comic strip, Mouse managed to divide his time between playing for Tottenford Rovers and studying at St Victor's Hospital as a medical student.
On a trip to watch Scotland playing, he met up with Hamish, who persuaded him to sign for Princes Park (conveniently Mouse was also able to transfer to a Scottish hospital to continue his studies).
In later years, the comic told the story of the pair transferring to Glengow Rangers where they were later joined by McWhacker (who promptly signed a number of their former Princes Park teammates).
The strip ran until May 1990, returned in July of the same year, and finally came to an end in January 1993 with reprints appearing in the remaining issues of the weekly Roy of the Rovers comic.
A rarity among the genre of football strips; the Hamish and Mouse story was extremely humorous in nature with unbelievable and exaggerated tricks and skills shown by the two lead characters, although they never degenerated into out and out pastiche in the style of Billy the Fish.
Overshadowed by the great sides of Glasgow Princes Park, the team languish at the foot of the Second division of the Scottish League, but manager Ian McWhacker is determined to achieve a vast improvement in the 1973-1974 season.
Crawford Town, a first-division English club, are the first to sign the new talent, with young Balfour debuting for them in a World Cup warm-up match against a South American team in London.
Hamish Balfour will give the Cup to Princes Park for the second time in 1982, promotion to the topflight again and two years later he will stand on the high pedestal of Scottish Football, the Premier Division title.
As the comic strip progresses, the Hebridiean giant, having already debuted for the Scotland national team, win his second cap in a match against Iceland in March 1985 under manager Ian McBossy.
He played in UEFA Cup with Tottenford Rovers but in 1985 he moved up north to Glasgow teaming up with the gentle giant Hamish Balfour for the sake of Princes Park.