The hotel traces its origins to 1844, when a two-story building known as El Cafe or The Escauriza Saloon was built at the site.

The two-story structure was owned by Manuel López and Urban González[2] and was designed in the neoclassical style.

[3] The Inglaterra was renovated again in 1901, with the addition of electricity, telephones, private bathrooms in each room, and a telegraph link.

On March 19, 2016, Starwood announced that the Inglaterra would become the first hotel in Cuba to be managed by an American company in over 55 years, joining The Luxury Collection division.

On June 5, 2020, Marriott was ordered by the U.S. Treasury to cease management of the Four Points by Sheraton by August 31 and not to open any other planned properties in Cuba, like the Inglaterra.