The first building at the site was a town house constructed by the nobleman Lave Brahe, who owned the estates Vittskövle and Krogholm in Scania.

The writer Bernhard Severin Ingemann who lived at Sorø Academy stayed in Hotel Royal during his visits to Copenhagen.

One day prior to her departure, on 21 October, she held a dinner there for her Copenhagen friends which included Hans Christian Andersen.

[2] Other notable guests include the German philosopher Friedrich Schleiermacher who stayed there during his visit to Copenhagen in 1833 and prime minister Carl Edvard Rotwitt who had his home there at the time of his early death in 1866.

He had taken over his father's small printing business in 1857 and later developed it into a successful newspaper publishing house, De Ferslewske Blade.

It was said about him that published Dagens Nyheder for the estate owners, Nationaltidende for the bourgeoisie of the bel étage, Dagbladet for the middle class on the second floor and Aftenposten Concierge in the basement.

It is run by the owners of the Vesterbro café Dyrehaven on Sønder Boulevard and the night club Bakken in Kødbyen.