Hotta Masatoshi (堀田 正俊, December 31, 1634 – October 7, 1684) was a daimyō (feudal lord) in Shimōsa Province, and top government advisor and official in the Tokugawa shogunate of Japan.
He served as personal secretary to the next shōgun, Tokugawa Ietsuna, for a time, before being appointed wakadoshiyori (junior councillor) in 1670.
At this time, another rōjū, Sakai Tadakiyo, in a bid for personal power, proposed that the next shōgun be selected from the princely houses.
However, Masatoshi, said to have been infuriated, voiced strong opposition to this scheme; Tadakiyo resigned his post shortly afterwards, and Ietsuna's brother Tokugawa Tsunayoshi was installed as the new shogun.
Following Masatoshi's death, Tsunayoshi took the opportunity to reorganize the shogunate's offices so as to weaken the rōjū and grant additional powers to the Soba-yōnin (Chamberlains).