However, accompanied by the eccentric and poor vet and tour guide, Pablito, whose children dislike him and deem him a liar, Dan is told the myth of the Marsupilami, a mythical and extremely rare creature that is believed to inhabit the Palombian rainforest and to be a real species.

Meanwhile, 80-year-old botanist Hermoso discovers a beautiful but rare orchid, in which the Marsupilami uses to cradle its eggs, manages to condense it into a liquid and drinks it, turning him to an early adult age.

In their temple, they meet the beautiful Queen Paya, who gives a prophecy of the Marsupilami (seen as the Guardian of the Jungle) being threatened by "the man with two faces".

Back in prison, the two find General Pochero, who manages to give in and escapes using a secret exit, arriving at the palace.

Because Pochero enjoys hearing Celine Dion's "I'm Alive", he disguises himself as a woman, using the costumes of his mannequins, and distracts the Palombian soldiers, giving Pablito and Dan the chance to steal the orchids, eggs and a limousine before returning to Chiquito.

Jamel Debbouze is set to return for the sequel, while Philippe Lacheau, Jean Reno, Élodie Fontan, and Tarek Boudali join the cast.