Twenty years later, a partially paralyzed Prendergast resurfaces in the United States as the rich philanthropist, John Pren.

The police discover Pren has been faking paralysis and has been killing off his backers by allowing Kali to attack them.

Prior to being released, The House of Mystery was prepared under the working titles The Ape and Curse of Kali by the studios Monogram Pictures.

[1] Also among the cast was Laya Joy, an interpretive dancer who changed her name from Joyzelle just prior to the release of the film.

Siodmak spoke of the adaptation, declaring that "whether it was The Ape, The Climax (1944), or I Walked with a Zombie (1943), I never used the original material.