The House of Tan Yeok Nee (Chinese: 陈旭年宅第 or 陈旭年大厦) is a mansion building located at the junction of Penang Road and Clemenceau Avenue in the Museum Planning Area in Singapore.

In 1907, the government transferred Tan's house to the Anglican Church, which established St Mary's Home and School for Eurasian Girls for 20,000 Straits dollars.

The expansion plan was dropped when the Teo family sold the hotel and its surrounding land, including the House to a consortium led by the Wing Tai Group in 1996 for S$380 million.

[7] University of Chicago Booth School of Business in 2000 for its Asian campus, before moving to Hong Kong in 2013, with the last Singapore cohort graduated in 2015.

In 2007, Wing Tai sold the House, with the adjacent redeveloped Visioncrest office block to Union Investment Real Estate AG for S$260 million.

With the wide array of beautifully restored traditional Chinese decorative elements and the convenience of present-day state-of-the-art technology around the house, this combination of 'old' and 'new' provides a unique environment rich in history and culture.

Pillars on the front door are made of marble with colourful carvings of stories reflecting the lives of Tan Yeok Nee's ancestors in Chaozhou.

The back of the house has a distinctive style exhibited by beams with special Teochew tiles, a main pillar decorated with gold-plated carvings, and a marble floor.

The structure exhibits the harmony of Yin and Yang, shown at the top of the ceiling in gold, wood, water, fire, and earth – the five elements.