A few months after the first film's events, Professor Roy Curien at the fictional Cuesta Verde University (CVU) in Seattle has managed to subdue and contain a "Hyper sapiens" specimen, who is revealed to be his son, Rudy Curien (a survivor of Isla del Morte incident).

They fight their way to the professor's laboratory, finding the original specimen still imprisoned and a pair of students, Lonny and Sarah, who had survived.

They enter the confinement room and extract blood from the zombie but are forced to kill it when it breaks free.

There, they prepare to rescue Alex and Ellis, but a zombie who was locked in the back of the van by the soldier assigned to guard it bites Rodriguez.

Henson executes Rodriguez, and the duo arrives in front of the science building as Alex and Ellis fight their way through a zombies horde.

On review aggregator Rotten Tomatoes, House of the Dead 2 holds a 25% approval rating from 4 critics.

But underneath all the pop culture banter lies an effective film, with some palpable tension and enough blood, grue and boobs to surprise even the most jaded zombie movie hater.

"[4] Jon Condit of Dread Central rated it 3/5 stars and wrote that it is deserving of a chance despite its flaws.

[5] Reviewing the DVD, Steve Barton of Dread Central rated it 3/5 stars and wrote, "It's semi-blood soaked, filled with zombies, open for business, and dare I say it, it's actually not a bad visit!

[7] Mark A. Altman said: "It's a completely different approach to the material than the first two films and I doubt it will even be called House of the Dead 3.

"[8] The film directed by Patrick Dinhut and starring Dean Cain, which ended up with the title Dead and Deader when premiered on Syfy in December 2006 and released straight-to-DVD in 2007.