[3] The hospital has earned worldwide recognition in multiple specialties including cardiovascular surgery, cancer, epilepsy treatment and organ transplantation.

[5] Originally located near downtown Houston, after a $1 million donation from Lillie and Hugh Roy Cullen, the hospital relocated to the Texas Medical Center and opened a 300-bed facility in 1951.

[7] In 1976, unusually heavy rains caused more than $20 million in flood-related damage in the Texas Medical Center, knocking out power at three hospitals.

[8] On June 8, 2001, Tropical Storm Allison dropped up to 37 inches of rain on parts of Houston, causing the worst flooding in the city's history up until that time, with serious damage to the Texas Medical Center.

[29] Houston Methodist is nationally ranked in ten specialties and achieved maximum points for superior performance in 17 out of 17 common adult procedures and conditions.

[1] Other affiliations include Texas A&M Health Science Center College of Medicine and the University of Houston.

[37] It was the nation's first hospital system to require its employees to get vaccinated against COVID-19,[38] a disease that, as of June 2021, had caused more than 3.7 million deaths worldwide.

[50] Many such lawsuits were backed by prominent anti-vaxxers like Robert F. Kennedy Jr.[51][52] The group of medical workers staged a walk out on June 7.

[53][54] U.S. District Judge Lynn Hughes dismissed the lawsuit on June 12, 2021, calling the plaintiff's allegations that the vaccine was experimental "false" and adding that the hospital's policy doesn't violate state or federal law and isn’t considered “coercion”.