In the film, Redman and Method Man portray two cannabis users who are visited by the ghost of a deceased friend after smoking his ashes.

Once there, they meet Bart (Chris Elwood), captain of the rowing team, his girlfriend Lauren (Lark Voorhies), I Need Money (Al Shearer), and their roommates Jeffrey (Justin Urich) and Tuan (Trieu Tran).

Once they are settled in, they visit Dean Carl Cain (Obba Babatundé) who tells them that per the terms of their scholarship, they must maintain a minimum grade point average of 2.0 in order to remain, or else face expulsion.

Silas continues to woo and study with Lauren, while Jamal dates the U.S. vice president's (Jeffrey Jones) daughter Jamie (Essence Atkins).

Also during the first half of the semester, they pull pranks and steal, which angers Bart, Jeffrey (who is pledging for a Final Club), and Dean Cain.

Before midterms Jamal suggests they go to a graveyard, dig up a "smart dead guy", and smoke his remains which they attempted to do so with John Quincy Adams.

Due to Gerald's abuse of the plant very little remains and Jamal and Silas continue to fail their classes, which pleases Dean Cain.

Jamal and Silas are proud that the serum worked, a celebration that was almost short-lived, as Dean Cain returns and unsuccessfully attempts to kill them both with an axe in anger.

The website's critical consensus reads, "How High is a sloppily constructed stoner movie filled with lame, vulgar jokes.

[10] In May 2002, a sequel to How High was reported as being written by Don D. Scott (the co-writer of Barbershop), with Method Man and Redman reprising their roles.

[11] In October 2008, Redman revealed that a script for the sequel was still in the middle of being written, stating that "we wanna represent all the smokers", believing that since How High, no one has done justice on a stoner film.

[12] In April 2009, it was reported that Redman blamed Universal Pictures for the film's delay, stating: "They're not opening that money door for us to shoot it.

[14] In April 2013, Method Man told TMZ that the script was being written by Dustin Lee Abraham, who wrote the first one, but it all would depend on Universal if the film would happen.