Klausner often prompts her guests to discuss things they would not typically be asked to talk about in a formal interview, such as their opinions on current reality TV shows, or gossip and stories from their early career.

[3] As a host, Klausner has been described as having a "literate sensibility and affection for showmanship," which inspires her to include the occasional song along with her rambling digressions on high and low culture.

[4] Regular subjects of Klausner's monologues include pets, television, film, musical theater, current events, American politics, what is happening on Twitter, and who she considers worthy of inclusion in a list known as the "Redhead Hall of Fame", using each topic as a platform for comedic improvisation and performance.

[4] Notable guests who have appeared on How Was Your Week include David Rakoff, Joan Rivers, Michael Ian Black, Jon Ronson, Patton Oswalt, Martha Plimpton, Ana Gasteyer, Kurt Loder, Retta, Eddie Pepitone, Chris Parnell, Mo Rocca, Jim Gaffigan, Carole Radziwill, Todd Oldham, Sandra Bernhard, Tom Scharpling, Andrew McCarthy, Mike Birbiglia, and Carrie Brownstein, among others.

[6] The first live recording of the show took place October 20, 2011 at The Bell House in Brooklyn, New York, and featured Ted Leo, Fred Armisen, Paul F. Tompkins and Billy Eichner.