Players play as one of three survivors - the all rounded Kenji, the fast, arczar Abbie or the brawling Jack - shipwrecked on one of four zombie-infested islands that form an archipelago.
The survivor soon meets Kovac, a mysterious man in full armor who has made the islands his personal hunting ground.
The survivor locates Emily, stranded on a cliffside, but is unable to save her from falling into the sea and getting swept away; Carol is devastated by the news.
After retrieving Enzo, the survivor learns from her of a drunken former airplane pilot named Sanchez who lives nearby.
Sanchez turns out to be a drug smuggler who lost all his cargo when his plane crashed, and the survivor is forced to comb the entire archipelago for his scattered packages to secure his cooperation.
He then sets the survivor a 'final exam' by attracting a massive zombie horde, which will have to be fought off while the plane starts up.
The game ends with Kovac causing another shipwreck by misguiding a ship over the radio, just as he did with the player's in the beginning.