Howe-Waffle House and Medical Museum is an 1889 Queen Anne style home in Santa Ana, California.

In the early 1970s, the City of Santa Ana slated the home for demolition in order to widen a road, but concerned area citizens joined forces to preserve the house.

Between March 27–29, 1975, the City moved the house to its present location on the corner of Civic Center and Sycamore.

The Society worked tirelessly over the years to restore the home to how it would have looked during Dr. Howe-Waffle's time.

The all volunteer Santa Ana Historical Preservation Society continues to run the home today as the Dr. Willella Howe-Waffle House and Medical Museum, and it is open for tours six times a year.