After graduating from Nanjing University with a major in English language and literature in 1992, Hua joined the Ministry of Foreign Affairs as a section member.

Her father was formerly secretary of the Chinese Communist Party Huai'an County Discipline Inspection Commission, and her mother was the deputy director of a local district.

In 2012, Hua was promoted to deputy director general of the Department of Press, Communication, and Public Diplomacy of the Ministry of Foreign Affairs.

[3] In February 2018, during a prolonged absence at the Foreign Ministry, there were reports that Hua was investigated for storing large amounts of U.S. dollars in her home.

[4] On July 18, 2019, she was appointed director general of the Foreign Ministry Department of Press, Communication and Public Diplomacy, succeeding Lu Kang.

[17]: 121  In 2020, she stated that she was "fine" being called a wolf-warrior diplomat as long as she defends the legitimate interests of China regarding sovereignty, security, and development.

[18] In 2020, Hua retweeted a story published by The Grayzone that claimed to debunk research into the internment camps in Xinjiang detaining Uyghurs.

"[22] In January 2021, Hua renewed the conspiracy theory that the SARS-CoV-2 virus originated in the United States at the Fort Detrick Army Medical Command Installation.

Her words quickly became a trending topic on the Chinese social media platform Weibo, and Hua continued to cite evidence on Twitter, while asking the government of the United States to open up Fort Detrick for further investigation to determine if it is the source of the SARS-CoV-2 virus.

[28] In April 2024, Hua posted several video screenshots and photos in the social media platform X showing American police crackdowns on large-scale campus protests against U.S. support for Israel.