The apogee of the settlement is estimated at the Ramos Phase (300 BCE – 200 CE), the period of Mesoamerican urban society's development.

The site was part of other early settlements in the region, such as Cerro de las Minas, Yucuita, Diquiyú and Monte Negro.

Their apogee is characterized by monumental architecture and sculptures, there is also evidence of clear social stratification within their residential zones.

[2] The foundation of this ancient prehispanic city goes back to 400 BCE, it was an important urban center up to 800 CE; it is a good sample of the early Mixtec culture, called Ñuu Sa Na' or "Ancient People" (Ñuu Yata in the Mixteca Baja).

[2] During their early urban stages, Huamelulpan and the main Mixtec centers maintained complex and variable relations with Monte Albán.

[5] The Huamelulpan archaeological site was discovered in 1933 by Alfonso Caso and many of the pieces found are in exhibition at the Town Community Museum.

[6] Jansen y Pérez Jimenez offer an alternative opinion, that the native name is Yucunundaua, which translates "Hill of the Wooden Columns".

During the transition from the mid-formative period (Late Cruz) to the late- formative (Early Ramos) the number of sites decreased in the studied area.

It is a striking fact because in Yucuita and Huamelulpan this period was a time of the major centralization and florescence of the regional states and general growth of the population.

The internal classification of the Mixtecan branch, i.e., the subgrouping between Trique, Cuicatec, and Mixtec proper, is an open question.

The Mixtec are well known in the anthropological world for their Codices, or phonetic pictures in which they wrote their history and genealogies in deerskin in the "fold-book" form.

Scholars have long identified a number of similarities between the ancient Guatemalan and Mexican art styles and cultures.

It is certain this route played a critical role in the political and economic development of southern Mesoamerica, although its importance varied over time.