Having passed his Abitur exams, he was called up for military service as a cadet in World War I, but soon was dismissed due to a pulmonary disease.

From 1920 onwards, Meyerinck starred as a silent film actor, whereby he developed a distinctive appearance with his high forehead and moustache, often emphasizing his hypnotic expression by sporting a monocle.

He was able to continue his career in the sound film era by his unmistakable rasping voice, which perfectly added to his physiognomy, having a standing order for scoundrels and charlatan roles.

The magazine Der Spiegel called Meyernick's role in numerous films a "comical Erich von Stroheim, who parodied Prussianism and made it ridiculous".

Hubert von Meyernick made one of his few Hollywood film appearances in Billy Wilder's film satire One, Two, Three (1961), portraying in a memorable supporting role the penniless aristocrat Count Waldemar von und zu Droste-Schattenburg, who adopts Horst Buchholz for financial reasons.