Most of Fregonese's American films were Westerns and crime melodramas, like Man in the Attic (1953) and Black Tuesday (1954).

He worked with renowned actors such as Gary Cooper, Barbara Stanwyck, Anthony Quinn, Edward G. Robinson, Luisa Vehil, Víctor Laplace, Soledad Silveyra, Paul Naschy, and Joel McCrea.

A former sports journalist, Fregonese attended Columbia University in 1935, and then was hired to be a technical advisor for films with Latin American themes.

[citation needed] Fregonese and actress Faith Domergue were married in secret in Ciudad Juárez on October 8, 1947, hours after she divorced bandleader Teddy Stauffer there.

While living in the city of Tigre Fregonese suffered a heart attack and died aged 78.