Huis Marseille focuses on photography that emphasizes an artistic visual language, characterized by a passionate spirit of inquiry and avant-garde innovation.

The museum has showcased works by renowned photographers such as Berenice Abbott, Deborah Turbeville, Cy Twombly, Samuel Fosso, Dana Lixenberg, Viviane Sassen, Bernd and Hilla Becher, Edward Burtynsky, and Deana Lawson.

In addition, the museum houses an extensive collection of contemporary photography, featuring works by artists including Jacqueline Hassink, Guy Tillim, Anton Corbijn, Thomas Struth, and Sophie Calle.

On the building's impressive, classical façade, Focquier placed a stone depicting the layout of the French port city of Marseille.

Focquier had distinguished himself and risen to the highest circles of Amsterdam, an elite class of affluent, self-assured men immortalized in group portraits such as Rembrandt’s Syndics of the Drapers' Guild (De Staalmeesters).

[5] In the current garden room hangs an original ceiling painting from 1730, specially created for the house by Jacob de Wit, the leading decorator of the 18th century.

The ceiling piece was housed in the Rijksmuseum for many years but returned to its original location in 2004, after a thorough restoration, on loan from the Royal Archaeological Society (Koninklijk Oudheidkundig Genootschap).