[2] The forest is bounded by the border with Rondônia to the south, the Madeira River to the west and the Trans-Amazonian Highway (BR-230) to the north.

[3] The national forest is in the lower plateau of the western Amazon, consisting of extensive flat areas with occasional formations of higher land.

The "white water" rivers draining the forest contain large amounts of sediment and form fertile floodplains.

[4] The Humaitá National Forest was created by decree 2.485 of 2 February 1998 and is administered by the Chico Mendes Institute for Biodiversity Conservation (ICMBio).

[4] An ordinance of 9 January 2012 provided for a consistent and integrated approach to preparing management plans for the conservation units in the BR-319 area of influence.