In December 1990, Laura Rodríguez became the first elected representative of any Humanist Party in the world after winning a seat as part of the Concertación coalition, after Augusto Pinochet handed over power.

For the 2005 presidential elections, the Humanist Party was a member of the coalition Juntos Podemos Más (Together We Can Do/Achieve More).

Their presidential candidate Tomás Hirsch won 5.4% of the vote in a 4-way race between Michelle Bachelet, Sebastián Piñera, and Joaquín Lavín in the 2005 elections.

On 12 March 2013 they selected economist and university professor Marcel Claude as their candidate for the 2013 presidential election.

Their presidential candidate was Beatriz Sánchez who won 20.3% of the votes, finishing in 3rd place; additionally, three deputies from the party were elected: Tomás Hirsch, Pamela Jiles and Florcita Alarcón.