Humboldt–Hospital is a Buffalo Metro Rail station located at the western terminus of Kensington Avenue and Main Street and is the only station with entrances on both sides of the Main Street for passengers to enter and exit from.

To not confuse, Kensington Avenue rejoins Main Street in Snyder, New York at its eastern terminus.

The area near the station is a mix of housing and medical offices, anchored by the Sisters of Charity Hospital.

The Parkside residential community is directly to the east of the station and is also a short distance from Delaware Park.

Humboldt–Hospital station is home of two pieces of work in the upper level, from Sharon Gold and Joyce Kozloff (New York City).