Humphrey Radcliffe (died 30 August 1566) was an English landowner and Member of Parliament.
He was a son of Robert Radcliffe, 1st Earl of Sussex and Elizabeth, a daughter of Henry Stafford, 2nd Duke of Buckingham.
[citation needed] Radcliffe was a Member of Parliament for Bedfordshire and for Maldon in 1558 jointly with Roger Appleton.
[1] Radcliffe, as Lieutenant of the Gentlemen Pensioners, is said to have spoken in favour of the Protestant writer Edward Underhill shortly before the wedding of Mary I of England and Philip II of Spain, and so Underhill was allowed to serve at the feast at Wolvesey Castle.
[2] Radcliffe obtained the manor of Elstow in Bedfordshire, a former convent, from his wife's family, it had been granted to her father at the dissolution of the monasteries.